| ncRNA name | DDAH2 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Macaca mulatta |
| Tissues/Cell_line | rhesus choroid-retinal endothelial cell line RF/6A |
| Methods | tube formation assay, EdU incorporation assay, transwell assay, DAPI staining, siRNA transfection, high-performance liquid chromatography (HPLC), qRT-PCR, Western blot |
| Expression pattern | associated |
| Functional description | ADMA contributes to the neovascularization of retina in diabetic mellitus. After knocking down DDAH1 or DDAH2, the levels of ADMA were significantly increased. Knockdown of DDAH1 or DDAH2 also significantly increased the tube formation of RF/6A cells. |
| PubMed ID | 29777874 |
| Year | 2018 |
| Title | Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway. |
| Drug-related ncRNA | NO |
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